Professor Emeritus and Past Chair Temple University School of Pharmacy Philadelphia, Pennsylvania
Scientists and practitioners are continually seeking new and better agents to treat diseases and reduce patient suffering. This relentless push is seen in the drive to develop new therapeutics for the treatment of acute pain. The development of new agents often begins with the most basic levels of research, identifying novel targets and improving on others. This course will discuss both early-stage research—investigating agents that work through a variety of innovative mechanisms, such as the delta and kappa opioid receptors—and reviewing agents that possess desirable characteristics and are closer to market, such as oliceridine, an agent designed to treat acute pain and reduce opioid side effects. We’ll also review and discuss how older drugs are being reformulated to improve their utility and efficacy and reduce their side effect profile. One example: converting older drugs into IV forms, such as the NSAID meloxicam, or reformulating a drug, such as the NSAID ketorolac, to allow it to be used for continuous infusion.
Describe what options for the treatment of acute pain have been recently made available for us in the United States
Discuss some of the new agents and their indications